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Saturday, 31 March 2012
Hearing Aid Vacuums Might Be Handy For Earbud Maintenance [Vacuums]
Mooresville Local Real Estate Agent For Gaining Quick Access To ...
Do you need quality Mooresville home listings and want to make some great savings too? Are you still unaware of best priced property deals in Mooresville, NC? Don?t you have a clue about a commendable real estate portal such as Property Hookup where the most recent and ranked Mooresville property information show up almost every day? Create a free sign up and start taking advantage of its individually ranked local property data and Mooresville local real estate agent listings that are screened before inclusion. It is committed to bring better options and minimize your efforts in the processing of deals through customized MLS listings service of an efficient real estate agent in North Carolina like Lisa Revis. Property Hookup has broadened the reach of its Mooresville local real estate agent network to manage your property needs better and faster. Additionally, you can initiate a search for real estate agent in North Carolina based on your preference and find the most suitable broker or realtor who can enhance your experience with advanced tools and techniques. It does not cost you anything for making a first approach to a qualified real estate agent in North Carolina like Lisa Revis on Property Hookup. If Mooresville deal perfection is what you like, Lisa Revis can ensure it in the most convenient manner. The best value property deals can?t be far away from you especially when a skillful North Carolina real estate agent, Lisa Revis is ready to assist you in any way. She is reachable through her Mooresville real estate agent listing on Property Hookup. Go for a free sign up and bank on her truly exceptional MLS listings and great realtor potential from now on.
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Nir Rheumadiagnostik ? The strength of Detox: Tips on how to ...
If you do not stay in the heart of the particular forest, a person breathe in simply pure air, feed on simply natural food items when you find yourself eager; and therefore those people food items supply the actual natural requirements of buikspier oefeningenyour physique; you certainly not encounter any sort of worry, worry as well as panic and you just activity daily? chances are that you must detoxing.
Similar to the particles and also crud this increases in the house demands once a year house-cleaning ? ?toxins?, extra pounds and also Goodness understands what precisely accumulate within your body.
We all need to try and do an ordinary house-cleaning ? and therefore suggests letting your system an opportunity to cure alone, launch extra pounds, launch their waste, and acquire a different brand new begin.
Your whole body comes with an wonderful self-healing system crafted directly in it all, but in sequence to permit it all get the job done, you should give it the others it takes.
For this reason starting a fast is a huge tradition part of quite a few global made use of, and also nearly every option health and fitness exercise endorses getting some sort of starting a fast as well as ?detox kuurdiet?.
Just what Detox Eating habits?
The ?detox diet? is not about attending a repair facility to get drug use. The idea of ?detox? has been used during natural bags in the sense of ?removing waste.? The detoxing diet regime will allow your system to clean alone of accumulated waste, worry, so helping it all launch unwanted fat and also pounds.
The detoxing meals are a fixed diet regime you comply with, often mixed with a fitness system, stay or even a couple of weeks (or simply for a longer period). It is really type of just like starting a fast, but it?s simpler to perform and you can now practice it in your own home when it?s needed.
Indications You?ll want to Detox
Always be in a position toafval tips recognize on your own when you wish to take a some sort of detoxing diet regime. If you want for on your own in the hand mirror and don?t just like what you see, you may not such as the extra pounds you have been carrying all around? after that detoxing diet regime will allow you to get back on course using a nutritious diet and also launch extra unwanted fat..
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One of the main primary advantages of owning your own private ...
Home ? General ? One of the main primary advantages of owning your own private teacher is really because show a number of innovative unique
Fitness professionals within Nj-new jersey, not just be professional professors but additionally will give you proper decide to exercise routine in order to meet your current spots. A non-public coach will help uou remove the handful of kilos, tone up ones own palms, completely deflate an individual?s stomach area and build that will appropriately toned shape.
Whilst hiring a Personal Trainer Chicago should must have an individual?s monetary along with point in time investment, he/she substitutes moving from generating a targeted exercise program for your needs. Fitness coaches make perfectly sure that they can explain to you every one activity, so you are aware easy methods to perform the exercising risk-free together with obtain obtain the most from the physical exercise. They additionally accurately look at an individual?s health and fitness, identify your current wellness and fitness needs and provide an exercise routine that is great for our bodies. And also they give you a innovative diet of which balances the actual conditioning regimen which was set for you will.
On the internet services Personal trainers can be zealous and are viewed as the most effective motivators. In cases where case you may not sense figuring out and also may want to omit your workout, ones dog trainer have been presently there to help you drive you to ultimately confines. Fitness instructors be working as a great resource connected with enthusiasm, intention, support and reassurance, that is everything that people need when it comes to themselves not to mention health and fitness.
One of the main benefits associated with home security system personal trainer is they present several different latest varied types for work outs inside your exercise regime. In addition effectively competent pro?s, they also have the action and data most recent activity strategies and what type of exercise movements might trust others. They are able to propose a diverse new selection of work outs for example Boxercise, meditation and then Pilates exercises for example in your own regime, the fact that in all likelihood you?ve got unknown or considered engaging in well before. Just by releasing these types of unique styles of workout routines in your own activity routines, your private coach can make training lessons a lot more intriguing and not as much lusterless.
Several catastrophes take place at the time of unsupervised workout plans, but when you?re all the wrists and hands to a conditioning personal trainer, they?ll make sure your personal wellbeing over the exercise routine workout. They will ensure that you have been keeping fit effectively in the exercise tools in order that you achieve utmost positive aspects and stay focussed. This helps reduce really serious overall health or perhaps actual physical injurious. By using a health and fitness private coach signifies that easier going with hitting the gym during a specific length of time as soon as lots of the fitness equipment along with kits will be available. That personal trainer would probably direct you not to mention adopt exact health concerns that will make sure you having injured.
After made up your mind to your workplace in opposition to your goals and achieve your prey, committing to a personal trainer in On the internet services almost always is an reliable program, that can assist one get through to your required variety of conditioning.
Source: http://www.jzuart.com/one-of-the-main-primary-advantages-of-owning-your-own-private-teacher-is-really-because-show-a-number-of-innovative-unique/
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5 Free Business Marketing Tools to Help You Work From Home Online
Business marketing tools are easy to do and to find. The internet has many options for letting other people know about a home based business. Marketing tools are necessary for the success of a business, but they do not have to be expensive since the internet offers many free tools.
Free Classified Ad Websites
A classified ad can become expensive when placed in the local paper, but some online websites are free to use. The ads will not take long to post, and they can be very effective to market a home online business at no cost. An individual can think of an eye-catching ad, and then he or she can post it to one of these free online websites to discover the new technology of advertising.
Social Networking Websites
Talking to many people is one way to promote a business. Social networks allow an individual access to hundreds of people without leaving home. With all the social networks available today, marketing a business from home has become easy and successful. Individuals can talk to people on these websites regularly to promote a business online. This one marketing tool is fun to use since it gives an individual the opportunity to connect with people all over the world.
Email Marketing
A simple and powerful way to let others know about a business is through email marketing. Some websites utilize this technology to create newsletters and promotions to send to a certain number of contacts for free. It is a very effective way to market a home based business without having the trouble or cost of paying postage to mail the information. It is a free way to advertise, but just be careful to make sure it is not considered spam mail, or the recipient may not see the mail.
Business Blogs
An individual can create a business blog to help market his or her work from home. Many businesses have home based blogs online. Therefore, someone can go to the other business blogs and post a comment, and then leave a link to his or her company?s website or business blog to direct traffic to his or her business. Just be sure to make a comment about the other business first before leaving the critical information about your company.
Business Forums
Place a post on different business forums on a regular basis to get traffic to your website. Home based forums are all over the internet, and some have enough traffic to promote or market a business. It will be easy to make other people aware of your website or blogs when a comment is made on another home business forum. Do this daily to keep people interested in your business.
More and more people have started working from home, and they have become successful at marketing their home business through these marketing tools. From advertising to forums, business marketing tools are available for those that are serious about working from home and need a way to promote a business.
This article was written by Matt B. ? Looking for cheap payday loans? Head over to CheapPaydayLoans.com to find the best rate.
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Flurry's analytics: Apple's App Store revenue still leading, but Amazon Appstore close behind
Flurry's analytics: Apple's App Store revenue still leading, but Amazon Appstore close behind originally appeared on Engadget on Sat, 31 Mar 2012 11:26:00 EDT. Please see our terms for use of feeds.
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A Romantic Family Garden Wedding. | New Selfishyayun
Are you planning an intimate wedding? Prepare a garden wedding at home. Such a fantastic idea, when it comes to making an option relating to a venue, you do not need to look any further than your family home and garden. Garden weddings are so intimate, the ideal setting for gorgeous pictures, to help keep the recollections alive for years to come.
The preparing starts with choosing exactly who the guests will be. Then the Weddings Invitations, should they be Customized, Personalized, Inventive, Designer or Theme Wedding Invitations. The very best point about going as well as a wedding theme is that you can pick the colors and the ribbons which go with a garden setting. This is a great concept, as it is possible to reproduce that in the wedding invitation stationery.
Develop that visual soft, romantic atmosphere by making use of a combination of varying shades, and fragile fabrics in white or cream. Use a great deal of soft table linens with classic overlays they are able to make a memorable statement. An excellent idea is if the parents or grandparents have lovely linens that could possibly be used.
A web-based wedding invitation store like LovelyLittleInvitations has the perfect wedding invitation packages for you. You may acquire wedding invitations which are custom created to pick up the style and color scheme, or pictures. You could possibly even choose on the internet wedding invitation cards. With this choice behind you, the real planning takes place. Getting a wedding and wedding ceremony party at home in the garden does not allow for many guests. Once you have selected the invites and sent them out for your family and friends, it is time to start organizing the garden for the special event.
You?ll find delightful methods to turn the garden in to an enchanting environment, a sparkling wonderland. Start off with stringing white lights around trees and from a single tree to the next. Provide every table a fairy tale name. Use chair covers and put a white sash around. Prior to the sash being tied place just one rose bud in each and every knot. Carnations and roses certainly are a sturdy flowers and work well for this.
In relation to the tables, place little earthen pots with seedlings in to be a party favor. Do keep the menu basic. Possibly go for buffet-style catering. Set a romantic tone with initialed or monogrammed serviettes to include a little elegance. Lastly use a floral topper for your wedding cake rather than a conventional cake topper.
Pay a visit to our on-line shop at LovelyLittleInvitations to get suggestions for styles that may tie your wedding invites towards the wedding reception.
For more information about Wedding Invitations visit our website: amazing site
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Sun Hung Kai dives as Kwok brothers arrested for graft
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?We use proprietary online gaming branding analysis software ...
Typically, many online gaming branding companies open their doors without thinking about production efficiency. This mistake, which is common, tends to put a damper on any ?quick? online gaming branding growth that contributes to profits. As a result, employees tend to be burdened with longer hours and highly demanding goals. The new computer models and their accompanying algorithms will prune off corporate waste, maintain employee positions, and most importantly boost profits on a global scale. It?s important to remember that these online gaming branding analysis computer models will not be replacing any human labor. ?If anything,? said Voltaire Aragan, President of Drennon Littleton Corp., ?we?ll be hiring MORE workers within the next 6 months. Why? Because while some jobs will be made redundant in the new profit model, we can take the talents of these valuable employees and parlay them into other, equally paying jobs within our corporate structure.? The news also bodes well for neigboring counties Iyo Hews and Alycia Boches to the north. Most businesses in these areas rely on the draw of a major retail mall, which brings inconsistent seasonal traffic. Instead, with new, fresh online gaming branding oriented business, local retailers and restaraunts believe the overflow business generated by the presence of large corporate populations will help drive the local economy to high levels. ?We?re excited to learn that over 1000 new jobs will be created,? said restaraunteur Pecka Agudelo, owner of Pecka Agudelo Italian Kitchen, ?the mall traffic is OK, but not very high quality. Now, with over 1000 new people visiting each day, business will surely skyrocket!? Creating computer models for online gaming branding analysis is a very difficult task. Generally speaking, it takes the combined talents of programmers with 20 years or more in experience with a variety of models. For the needs of the online gaming branding data analysis project, programmers Mila Colan and Claire Clanin utilized MySQL database, Java, PERL, and C#. The final programs were compiled in C#, while all text applications for the online gaming branding project were compiled in PERL. ?We chose to use PERL in our online gaming branding text studies because it is a lingual programming language,? said Blubaugh Hewey, head programmer, ?and also because it is easy to combine with other programming languages. PERL is easily installed on Linux platforms, and modules can be compiled that allow us to communicate with database technologies.? As a result, Blubaugh Hewey?s company, Steedman Basley INC expects to triple profits in the coming year. ?With increased profits, we?ll be able to hire more employees and really grow our business,? said HR Consultant Venetta Hanohano, who works with the company in managing recruitment. Some online gaming branding companies in the local industrial complex predicted that new hiring cycles would begin as soon as next week. All those interested in working in the online gaming branding industry are asked to compose a relevant CV or Resume and submit to each company?s HR department. All interviews will be done blind, so as to assure complete fairness in the hiring process. ?I expect hiring to wind down within 5 months,? said Gitthens Ewig, CIO of Tua Candler Partners Ltd., ?mostly because we?ll need time to train these employees to be as effective online gaming branding producers as possible.? ?I?d like to personally thank Spadoni Minner and Fjeseth Viereck for the work they?ve done on this project,? said CEO Voltin Riggans, ?without their efforts, our company would need be able to meet the demands of the burgeoning consumer market. When demand increases, the only way to provide for this change is an increase in technology. Most importantly, we won?t be laying anyone off. All current employees in our Doceti Valme County plant, and all online gaming branding project employees, will be guaranteed employment for 3 years.? News of the online gaming branding analysis projects was broke by reporter Platter Feltman, a high technology consultant and local newspaper writer. ?I was thrilled to hear this news,? said Platter Feltman, ?on more than just one level: As a reporter, it?s a great story, and as a citizen of Hindbaugh Nicotera Borough, I know that my neighbors will still have their jobs. One has to realize that this will only strengthen the local economy and drive new business to our area. These factors are key to economic survival and to my fellow citizens as we move forward in the next few years.?
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Friday, 30 March 2012
Autism rates up; screening, better diagnosis cited
Christopher Astacio reads with his daughter Cristina, 2, recently diagnosed with a mild form of autism, in her bedroom on Wednesday, March 28, 2012 in New York. (AP Photo/Bebeto Matthews)
Christopher Astacio reads with his daughter Cristina, 2, recently diagnosed with a mild form of autism, in her bedroom on Wednesday, March 28, 2012 in New York. (AP Photo/Bebeto Matthews)
Christopher Astacio reads with his daughter Cristina, 2, recently diagnosed with a mild form of autism, in her bedroom on Wednesday, March 28, 2012 in New York. (AP Photo/Bebeto Matthews)
Christopher Astacio stands in the doorway watching, as his daughter Cristina, 2, recently diagnosed with a mild form of autism, plays in her bedroom on Wednesday, March 28, 2012 in New York. (AP Photo/Bebeto Matthews)
Cristina Astacio, 2, recently diagnosed with a mild form of autism, reacts as reads with her dad Christopher Astacio on Wednesday, March 28, 2012 in New York. (AP Photo/Bebeto Matthews)
ATLANTA (AP) ? Autism cases are on the rise again, largely due to wider screening and better diagnosis, federal health officials said Thursday.
The rate of U.S. cases of autism and related disorders rose to about 1 in 88 children. The previous estimate was 1 in 110.
The new figure is from the latest in a series of studies that have been steadily increasing the government's autism estimate. This new number means autism is nearly twice as common as officials said it was only five years ago, and likely affects roughly 1 million U.S. children and teens.
Health officials attribute the increase largely to better recognition of cases, through wide screening and better diagnosis. But the search for the cause of autism is really only beginning, and officials acknowledge that other factors may be helping to drive up the numbers.
"We're not quite sure the reasons for the increase," said Coleen Boyle of the Centers for Disease Control and Prevention.
Autism is diagnosed by making judgments about a child's behavior; there are no blood or biologic tests. For decades, the diagnosis was given only to kids with severe language and social impairments and unusual, repetitious behaviors. The definition of autism has gradually expanded, and "autism" is now shorthand for a group of milder, related conditions, including Asperger's syndrome. Meanwhile, there's been an explosion in autism-related treatment and services for children.
As in the past, advocacy groups seized on the new numbers as further evidence that autism research and services should get greater emphasis. The new figures indicate "a public health emergency that demands immediate attention," said Geraldine Dawson, chief science officer for the advocacy group Autism Speaks.
The CDC study released Thursday is considered the most comprehensive U.S. investigation of autism prevalence to date. Researcher gathered data from areas in 14 states ? Alabama, Arizona, Arkansas, Colorado, Florida, Georgia, Maryland, Missouri, New Jersey, North Carolina, Pennsylvania, South Carolina, Utah and Wisconsin.
They looked specifically at 8-year-old children because most autism is diagnosed by that age. They checked health and school records to see which children met the criteria for autism, even if they hadn't been formally diagnosed. Then, the researchers calculated how common autism was in each place and overall.
An earlier report based on 2002 findings estimated that about 1 in 150 children that age had autism or a related disorder such as Asperger's. After seeing 2006 data, the figure was revised to about 1 in 110. The estimate released Thursday, based on 2008 data, is 1 in 88.
The study also found that autism disorders were almost five times more common in boys. And that an increasingly large proportion of children with autism have IQs of 85 or higher ? a finding that contradicts a past assumption that most autistic kids had IQs of 70 or lower.
Also, higher autism rates were found in some places than others. For example in Utah, as many as 1 in 47 of the 8-year-olds had an autism spectrum disorder. In New Jersey, 1 in 49 did.
Alabama was at the other end the scale, with only about 1 in 210 identified as autistic. The difference was attributed to less information out of Alabama. Researchers were not able to access school information in that state and a few others, and as a result believe they have a less complete picture.
That's a reasonable explanation, said Zachary Warren, director of an autism treatment and research institute at Vanderbilt University.
"How you go looking for something is going to affect what you find," he said.
In the early 1990s, only a few out of every 10,000 children were diagnosed with the condition, based on some small studies in individual states or cities. But the numbers began to change dramatically after 2000, when Congress directed federal health officials to do more autism research, and CDC started the larger study to see how common autism is.
CDC is also studying the cause of autism, which has remained a mystery.
Genetics is believed to play a role. Some parents and others have believed childhood vaccines trigger autism, even though many studies have not found a connection.
CDC researchers are looking at other possible factors, including illnesses that mothers had while they were pregnant with children who later were diagnosed as autistic. The researchers also are looking into medications that the pregnant women took and those given to their children took when they were young. The first results of that study are expected next year.
___
AP Medical Writer Lindsey Tanner in Chicago contributed to this report.
___
Online:
CDC: http://www.cdc.gov/autism
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Technology Properties Limited Files New 337 Complaint Regarding ...
On March 26, 2012, Technology Properties Limited LLC (?TPL?) filed a complaint requesting that the ITC commence an investigation pursuant to Section 337.
The complaint alleges that the following entities (collectively, the ?Proposed Respondents?) unlawfully import into the U.S., sell for importation, and/or sell within the U.S. after importation certain computers and computer peripheral devices, components thereof, and products containing the same that infringe one or more claims of U.S. Patent Nos. 6,976,623 (the ?623 patent), 7,162,549 (the ?549 patent), 7,295,443 (the ?443 patent), 7,522,424 (the ?424 patent), 6,438,638 (the ?638 patent), and 7,719,847 (the ?847 patent):
- Acer Inc. of Taiwan
- Brother Industries, Ltd. of Japan
- Canon Inc. of Japan
- Dane-Elec Memory of France
- Dell Inc. of Round Rock, Texas
- Falcon Northwest Computer Systems, Inc. of Medford, Oregon
- Fujitsu Limited of Japan
- Jasco Products Company of Oklahoma City, Oklahoma
- Hewlett-Packard Company of Palo Alto, California
- HiTi Digital, Inc. of Taiwan
- Kingston Technology Company, Inc. of Fountain Valley, California
- Micron Technology, Inc. of Boise, Idaho
- Lexar Media, Inc. of Fremont, California
- Microdia Limited of San Jose, California
- Newegg Inc. of City of Industry, California
- Rosewill Inc. of City of Industry, California
- Sabrent of Chatsworth, California
- Samsung Electronics Co., Ltd. of Korea
- Seiko Epson Corporation of Japan
- Shuttle Inc. of Taiwan
- Systemax Inc. of Port Washington, New York
According to the complaint, TPL is the exclusive licensee of the asserted patents, all of which are?generally directed to flash memory readers.? The ?623 patent discloses a memory card apparatus having more than one interface to read at least two different types of memory cards, allowing faster data transfer between flash cards.? The ?549 patent is directed to a system with a controller chip that interfaces with a flash memory card and can conduct bad block mapping to reduce errors.? The ?443 patent discloses a multi-media memory adapter capable of receiving multiple types of flash memory cards.? The ?638 patent is directed to a multi-flash card reader that uses a converter chip to read data from different kinds of flash cards.? The ?424 patent and the ?847 patent are both directed to an apparatus with a port having multiple sets of contact pins adapted to interface with different types of flash memory cards.
The complaint describes the infringing activities of each of the Proposed Respondents separately and specifically identifies a number of allegedly infringing products associated with each of the various Proposed Respondents, including, among other items, lap tops, card readers, and printers.
With regard to related litigation, the complaint states that TPL is concurrently filing civil actions in the U.S. District Court for the Eastern District of Texas accusing the same parties of infringing the asserted patents.? ASUSTek Computer Inc. filed a declaratory judgment of noninfringement against TPL and other parties in February, 2008 based on the ?623 patent and the ?638 patent, among other patents.? Soon after, TPL filed two suits against ASUSTek Computer Inc. in the U.S. District Court for the Eastern District of Texas, one alleging infringement of the ?443 and ?549 patents, and one alleging infringement of the ?623 patent, among others.? These cases have all been dismissed based on settlement.? TPL filed a complaint for violation of Section 337 against 18 respondents in relation to the ?623, ?443, ?549, and ?424 patents (Investigation No. 337-TA-807, see our August 26, 2011 post for more details).? This case is still pending at the ITC with 5 respondents remaining.? TPL also filed a complaint against the same 18 defendants in the U.S. District Court for the Eastern District of Texas for infringement of the? ?623, ?443, ?549, and ?424 patents, and this case has been stayed pending resolution of the 337-TA-807 investigation.
TPL asserts that it meets both the economic and technical prongs of the domestic industry requirement, arguing primarily that it has ?made substantial investments in the exploitation of the Asserted Patents through its significant licensing activities, which have resulted in numerous licensees whose products practice the inventions claimed in the ?424, ?443, ?549, ?623, ?638, and ?847 Patents.?? TPL bases this argument on the fact that that its predecessor in interest developed the products and technology that form the ?CORE Flash Patent Portfolio,? and made significant investments in plants, equipment, labor, and capital, resulting in extensive use of the inventions claimed in the asserted patents.? TPL argues that it meets the domestic industry requirement by continuing to make substantial investments in licensing this portfolio, including employing a ?team of IP legal and Research and Development employees who have worked to analyze and license the CORE Flash Portfolio.?
With respect to potential remedy, the complaint requests the Commission to issue permanent limited exclusion and cease and desist orders directed at the Proposed Respondents and their allegedly infringing devices.
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Many Cancer 'Discoveries' Don't Hold Up, Researcher Says
By Sharon Begley
NEW YORK (Reuters) - A former researcher at Amgen Inc has found that many basic studies on cancer -- a high proportion of them from university labs -- are unreliable, with grim consequences for producing new medicines in the future.
During a decade as head of global cancer research at Amgen, C. Glenn Begley identified 53 "landmark" publications -- papers in top journals, from reputable labs -- for his team to reproduce. Begley sought to double-check the findings before trying to build on them for drug development.
Result: 47 of the 53 could not be replicated. He described his findings in a commentary piece published on Wednesday in the journal Nature.
"It was shocking," said Begley, now senior vice president of privately held biotechnology company TetraLogic, which develops cancer drugs. "These are the studies the pharmaceutical industry relies on to identify new targets for drug development. But if you're going to place a $1 million or $2 million or $5 million bet on an observation, you need to be sure it's true. As we tried to reproduce these papers we became convinced you can't take anything at face value."
The failure to win "the war on cancer" has been blamed on many factors, from the use of mouse models that are irrelevant to human cancers to risk-averse funding agencies. But recently a new culprit has emerged: too many basic scientific discoveries, done in animals or cells growing in lab dishes and meant to show the way to a new drug, are wrong.
Begley's experience echoes a report from scientists at Bayer AG last year. Neither group of researchers alleges fraud, nor would they identify the research they had tried to replicate.
But they and others fear the phenomenon is the product of a skewed system of incentives that has academics cutting corners to further their careers.
George Robertson of Dalhousie University in Nova Scotia previously worked at Merck on neurodegenerative diseases such as Parkinson's. While at Merck, he also found many academic studies that did not hold up.
"It drives people in industry crazy. Why are we seeing a collapse of the pharma and biotech industries? One possibility is that academia is not providing accurate findings," he said.
BELIEVE IT OR NOT
Over the last two decades, the most promising route to new cancer drugs has been one pioneered by the discoverers of Gleevec, the Novartis drug that targets a form of leukemia, and Herceptin, Genentech's breast-cancer drug. In each case, scientists discovered a genetic change that turned a normal cell into a malignant one. Those findings allowed them to develop a molecule that blocks the cancer-producing process.
This approach led to an explosion of claims of other potential "druggable" targets. Amgen tried to replicate the new papers before launching its own drug-discovery projects.
Scientists at Bayer did not have much more success. In a 2011 paper titled, "Believe it or not," they analyzed in-house projects that built on "exciting published data" from basic science studies. "Often, key data could not be reproduced," wrote Khusru Asadullah, vice president and head of target discovery at Bayer HealthCare in Berlin, and colleagues.
Of 47 cancer projects at Bayer during 2011, less than one-quarter could reproduce previously reported findings, despite the efforts of three or four scientists working full time for up to a year. Bayer dropped the projects.
Bayer and Amgen found that the prestige of a journal was no guarantee a paper would be solid. "The scientific community assumes that the claims in a preclinical study can be taken at face value," Begley and Lee Ellis of MD Anderson Cancer Center wrote in Nature. It assumes, too, that "the main message of the paper can be relied on ... Unfortunately, this is not always the case."
When the Amgen replication team of about 100 scientists could not confirm reported results, they contacted the authors. Those who cooperated discussed what might account for the inability of Amgen to confirm the results. Some let Amgen borrow antibodies and other materials used in the original study or even repeat experiments under the original authors' direction.
Some authors required the Amgen scientists sign a confidentiality agreement barring them from disclosing data at odds with the original findings. "The world will never know" which 47 studies -- many of them highly cited -- are apparently wrong, Begley said.
The most common response by the challenged scientists was: "you didn't do it right." Indeed, cancer biology is fiendishly complex, noted Phil Sharp, a cancer biologist and Nobel laureate at the Massachusetts Institute of Technology.
Even in the most rigorous studies, the results might be reproducible only in very specific conditions, Sharp explained: "A cancer cell might respond one way in one set of conditions and another way in different conditions. I think a lot of the variability can come from that."
THE BEST STORY
Other scientists worry that something less innocuous explains the lack of reproducibility.
Part way through his project to reproduce promising studies, Begley met for breakfast at a cancer conference with the lead scientist of one of the problematic studies.
"We went through the paper line by line, figure by figure," said Begley. "I explained that we re-did their experiment 50 times and never got their result. He said they'd done it six times and got this result once, but put it in the paper because it made the best story. It's very disillusioning."
Such selective publication is just one reason the scientific literature is peppered with incorrect results.
For one thing, basic science studies are rarely "blinded" the way clinical trials are. That is, researchers know which cell line or mouse got a treatment or had cancer. That can be a problem when data are subject to interpretation, as a researcher who is intellectually invested in a theory is more likely to interpret ambiguous evidence in its favor.
The problem goes beyond cancer.
On Tuesday, a committee of the National Academy of Sciences heard testimony that the number of scientific papers that had to be retracted increased more than tenfold over the last decade; the number of journal articles published rose only 44 percent.
Ferric Fang of the University of Washington, speaking to the panel, said he blamed a hypercompetitive academic environment that fosters poor science and even fraud, as too many researchers compete for diminishing funding.
"The surest ticket to getting a grant or job is getting published in a high-profile journal," said Fang. "This is an unhealthy belief that can lead a scientist to engage in sensationalism and sometimes even dishonest behavior."
The academic reward system discourages efforts to ensure a finding was not a fluke. Nor is there an incentive to verify someone else's discovery. As recently as the late 1990s, most potential cancer-drug targets were backed by 100 to 200 publications. Now each may have fewer than half a dozen.
"If you can write it up and get it published you're not even thinking of reproducibility," said Ken Kaitin, director of the Tufts Center for the Study of Drug Development. "You make an observation and move on. There is no incentive to find out it was wrong."
(Note: Amgen researcher C. Glenn Begley is not related to the author of this story, Sharon Begley)
(Reporting By Sharon Begley; Editing by Michele Gershberg and Maureen Bavdek)
Earlier on HuffPost:
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Thursday, 29 March 2012
Building an Email List That is Effective
List building is one of the most vital tasks of internet marketing. Without having a list at hand, you won?t be able to build a long term business on the Internet. All internet marketers will tell you that the list generates the money. So if you haven?t started to build your list yet, now?s the time. But plenty of IMers are overwhelmed when it comes to creating a list, but they should not be. Read this article and look at the three tips that are provided for building a good list.
If you truly want to build an email list that lasts then you should try leveraging someone else?s list. All you have to do is locate some webmasters, blog owners or others with lists of their own on a topic that?s similar to yours. Joint ventures can often be arranged if you?re willing to take the first step and contact such list owners. You?ll have to come up with some content or something the list owner?s subscribers might want; this is your bargaining chip. This should be something of some value, such as a product you?re selling (either your own or one you have the right to sell). The point, of course, is to insert your own link with this gift, so your own list will start to get bigger. Everyone wins this way! The only kind of subscribers you want are relevant ones; that is, people who really care about your topic or product. The key to a successful list is having subscribers that you?ve targeted by their interests, needs, buying behavior, etc. What?s the secret to accomplishing this? By focusing on the right traffic sources. The key, then, is to make sure your opt-in forms or landing pages are receiving highly targeted traffic. To get the appropriate kind of subscribers for your list, you have to start with traffic that comes from highly relevant sources. You want the people on your list to be truly interested in what you?re sending them. You don?t want just any traffic coming to your landing page; it has to be the kind that?s just right for your list.
Last, be certain that your landing page has a link to your privacy policy for everyone to see. The reason for this is simple, people want to be sure of the fact that they won?t get spammed, so give then that surety. This tells them that you will keep their email address private. Make sure that your privacy policy is up to date and complete. When you fail to do this, it will decrease your chance of getting more sales. Something like this may not seem like a priority, but it is very important.These same tools are used by people in MLM Marketing
Every single move you make toward forming your email list will eventually help you get all that you can out of your web business. Your email list is an asset that can help you make your online business successful. This is an asset that you can leverage whenever you want. At your expense, it is an economic machine.
So if you haven?t started to create your list, you need to do so at once. Make some tangible moves in creating your list and you?ll be there instantly. You just need to remember, no matter what you do, you need to have morals with your maneuvers.
Dawn Masterall is a known writer, One of the major achievement of his success is through blogging. Blogs on different topics like internet business,mlm, affiliate marketing etc . He has done a great work on topics such as MLM lead systems and LifeWave
Source: http://www.thirdagemedia.com/building-an-email-list-that-is-effective-3/
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Chevrolet set to debut GogoLink navigation on Spark and Sonic rides (video)
Cruising around town in a gas-saving Chevrolet Sonic? Or perhaps you've got your name written all over the 2013 Spark's waiting list? Well, GM has some good news to share. Starting in the fall, those of you with a MyLink system on either of these rides will be able to add GogoLink navigation for around $50. The service's features include live traffic, emergency info, 3D maps, Google local search and native maps storage on smartphones to use for turn-by-turn directions when you can't get a signal. GM's saying that since GogoLink won't be out until the Spark's electrifying release, you'll have to make a quick pit stop by the dealer to get the app installed on your 7-inch infotainment slab. What's a few extra bucks to save you from getting lost, right?
Continue reading Chevrolet set to debut GogoLink navigation on Spark and Sonic rides (video)
Chevrolet set to debut GogoLink navigation on Spark and Sonic rides (video) originally appeared on Engadget on Wed, 28 Mar 2012 20:57:00 EDT. Please see our terms for use of feeds.
Permalink |GM | Email this | CommentsSource: http://www.engadget.com/2012/03/28/gm-chevrolet-spark-sonic-gogolink-navigation/
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Global Wind Composites Material Market Future Discussed in New Report Published at MarketPublishers.com
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Source: http://news.yahoo.com/global-wind-composites-material-market-future-discussed-report-172028627.html
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Raw and Vegan Hot Chocolate Recipe | Real Raw Health
This recipe takes a bit of time, you can make it quicker by keeping prepared nut milk in the fridge and using cacao powder rather than nibs (although I much prefer the taste of the nibs).
What you?ll need (serves 2):
- small handful of nuts (we like almond cashew or hazelnut)
- 1 cup of filtered water
?????????? *This is to make the nut milk, alternatively you can just use a cup of nut milk you have on hand
- 1 tsp vanilla
- 4 tbsp raw cacao nibs OR 3 tbsp raw cacao powder
- 2 tbsp honey (to taste)
- 5-10 drop stevia (to taste)
- 2 cups filtered water
What to do:
- If you are using cacao nibs, you?ll have to grind them into a fine powder. We use a coffee bean grinder, but a regular ol? mortar and pestle would do the trick. Whatever you have on hand, but it has to be a very fine powder.
- Mix the nuts and the water in your blender (skip this and the next step if you already have nut milk on hand).
- Filter the nut milk in a nut milk bag. (If you skip this step, your drink will be grainy and not as enjoyable)
- Pour the nut milk back into the blender.
- Add the cacao powder, vanilla, honey and stevia. Blend on high.
- Meanwhile, heat up the rest of your water in a kettle or on the stove. You can better control the temperature by doing it on the stove.
- Pour your cacao mixture into two cups, they should be about 1/3 to 1/2 full. No more than 1/2 or you won?t get very warm chocolate. It might take once or twice before you get the measurement right for your cups.
- Fill the cups with warm or hot water, whatever your preference. Remember you are mixing a room temperature liquid with the hot water, so it?s not going to be as hot as if you just boiled the kettle. The benefit is that it?s still nice and warm, and you don?t have to wait 5 minutes for it to cool off before you can drink it. And you are going to be drinking up all those delicious antioxidants while they are still useable.
- Make sure to stir with a spoon before drinking.
If you just can?t seem to get the measurement right and are always coming out with not enough or too much cacao mixture before you add the hot water, try starting out by measuring your nut milk in the cups. Pour the right amount of nut milk into the cups, and only use this to make the cacao mix. It takes all the guesswork out of it.
Making your own hot chocolate is a truly fun experience! Good quality cacao nibs don?t taste horrible like the old cocoa powder that mom used to bake with either. Real cacao is still bitter, but in my opinion still has a distinctly alluring flavor. You can try lots of different variations on this recipe as well. We like to add a few drops of almond extract or a 1/2 tsp of cinnamon (I wouldn?t recommend both at once, but to each their own). Chocolate goes very well with spice, so try adding some chili or cayenne pepper. A few drops of mint extract is also delicious and reminds me a bit of the holidays.
What is your favorite thing to have in hot chocolate? Share it below!!
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Source: http://realrawhealth.com/raw-hot-chocolate-recipe/
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Regular chocolate eaters are thinner
Tuesday, March 27, 2012
Katherine Hepburn famously said of her slim physique: "What you see before you is the result of a lifetime of chocolate." New evidence suggests she may have been right.
Beatrice Golomb, MD, PhD, associate professor in the Department of Medicine at the University of California, San Diego, and colleagues present new findings that may overturn the major objection to regular chocolate consumption: that it makes people fat. The study, showing that adults who eat chocolate on a regular basis are actually thinner that those who don't, will be published online in the Archives of Internal Medicine on March 26.
The authors dared to hypothesize that modest, regular chocolate consumption might be calorie-neutral ?in other words, that the metabolic benefits of eating modest amounts of chocolate might lead to reduced fat deposition per calorie and approximately offset the added calories (thus rendering frequent, though modest, chocolate consumption neutral with regard to weight). To assess this hypothesis, the researchers examined dietary and other information provided by approximately 1000 adult men and women from San Diego, for whom weight and height had been measured.
The UC San Diego findings were even more favorable than the researchers conjectured. They found that adults who ate chocolate on more days a week were actually thinner ? i.e. had a lower body mass index ? than those who ate chocolate less often. The size of the effect was modest but the effect was "significant" ?larger than could be explained by chance. This was despite the fact that those who ate chocolate more often did not eat fewer calories (they ate more), nor did they exercise more. Indeed, no differences in behaviors were identified that might explain the finding as a difference in calories taken in versus calories expended.
"Our findings appear to add to a body of information suggesting that the composition of calories, not just the number of them, matters for determining their ultimate impact on weight," said Golomb. "In the case of chocolate, this is good news ?both for those who have a regular chocolate habit, and those who may wish to start one."
###
University of California - San Diego: http://www.ucsd.edu
Thanks to University of California - San Diego for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/118733/Regular_chocolate_eaters_are_thinner
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